Sunday, February 3, 2013

North Korea threatens US over rocket launches

SEOUL, South Korea (AP) ? North Korea is threatening to retaliate for what it calls U.S. double standards over recent rocket launches by Pyongyang and U.S. ally Seoul.

A North Korean Foreign Ministry spokesman did not elaborate on what that might entail in his comments Saturday to the official Korean Central News Agency. But Pyongyang has recently threatened to conduct its third nuclear test in response to what it calls U.S. hostility.

Washington says Seoul's rocket launch Wednesday had no military intent while Pyongyang's in December was a test of banned ballistic missile technology.

The U.N. Security Council has imposed new sanctions on Pyongyang for its launch. Pyongyang says it should be allowed to launch satellites for peaceful purposes.

Both Koreas say their satellites are working properly. U.S. experts say Pyongyang's satellite is apparently malfunctioning.

Source: http://news.yahoo.com/north-korea-threatens-us-over-rocket-launches-083555975.html

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/282203387?client_source=feed&format=rss

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Placental blood flow can influence malaria during pregnancy

Friday, February 1, 2013

Malaria in pregnancy causes a range of adverse effects, including abortions, stillbirths, premature delivery and low infant birth weight. Many of these effects are thought to derive from a placental inflammatory response resulting from interaction of infected red blood cells with the placental tissue. In a study published in the latest issue of the journal PLOS Pathogen*, a researchers' team led by Carlos Penha-Gon?alves at the Instituto Gulbenkian de Ci?ncia (IGC), Portugal, observed, for the first time, the mouse placental circulation and showed how it can influence the malaria parasite behavior and infection. Their results indicate a higher accumulation of parasites in placental regions with low blood flow, being these areas more prone to an inflammatory response.

In humans, red blood cells infected with the malaria parasite, Plasmodium falciparum, accumulate in the placenta via interaction with a molecule expressed on the placental tissue ? a process called sequestration. In response to this event, placental cells secrete substances that recruit inflammatory cells leading to placental damage and negatively impacting fetal growth. Until now placental circulation has not been linked to the infected red blood cell sequestration. In fact, it is not trivial to investigate this hypothesis in human placenta, due to technical constraints

Luciana Moraes, an investigator of Carlos Penha-Gon?alves laboratory, has provided new insights to this issue by developing an experimental system that allowed the live observation of the blood flow in the mouse placenta. Mating two strains of mice, one of them with cells stained with a colorful marker, Luciana was able to identify the placental tissue (fetus origin). In collaboration with Carlos Tadokoro's laboratory at the IGC, the investigators developed a microscopy technique that allowed the observation of the placenta in a living mouse. Immediately before exposure to the microscope the mouse was injected with a fluorescent substance that labels the blood. With this set-up it was possible to distinguish maternal blood and placental tissue. The results showed for the first time how the circulation occurs in the placenta, and that the blood flows with different speeds in different regions of the placenta.

Next, the investigators infected red blood cells with the malaria parasite Plasmodium berghei, stained with a different color, and observed ? live ? the behavior of the parasite inside the placenta. They observed that in the areas with higher blood flow, the parasite never stops moving and does not interact with the placental tissue. The accumulation of parasite just occurs in areas of low or absence of flow. In these regions, placental macrophages engulf the infected red blood cells to attempt parasite clearance. Their observations also suggest that movements of the placental tissue may control the blood flow.

Luciana Moraes says: "Our results indicate that binding of infected red blood cells to a molecule expressed in the placenta may not be the only mechanism of parasite sequestration. The dynamics of placental circulation may also play an important role, and should be considered when designing therapeutics."

Carlos Penha-Gon?alves adds: "This is the first study done that shows live how placental blood circulation impacts on the local infection by the malaria parasite. It would be interesting and worthwhile to explore if a similar process occurs in the placenta of humans, taking in consideration that microcirculation in human placenta is quite different."

###

Instituto Gulbenkian de Ciencia: http://www.igc.gulbenkian.pt

Thanks to Instituto Gulbenkian de Ciencia for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126589/Placental_blood_flow_can_influence_malaria_during_pregnancy

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Saturday, February 2, 2013

Australia protests over whaling ship

Australia has protested to Japan after a vessel from its whaling fleet entered Australia's exclusive economic zone in the Southern Ocean.

Environment Minister Tony Burke said Australia had made it clear to Japan that whaling vessels were not welcome.

Japan's fleet hunts whales each year as part of what it says is a scientific research programme.

Australia is taking legal action against the whaling in an international court.

There has been a ban on commercial whaling for 25 years, but Japan catches about 1,000 whales each year for what it calls research. Critics say it is commercial whaling in another guise.

Continue reading the main story

The Legalities of Whaling

  • Objection - A country formally objects to the International Whaling Commission (IWC) moratorium, declaring itself exempt. Example: Norway
  • Scientific - A nation issues unilateral "scientific permits"; any IWC member can do this. Example: Japan
  • Indigenous (aka Aboriginal subsistence) - IWC grants permits to indigenous groups for subsistence food. Example: Alaskan Inupiat

The vessel - a support ship providing security to the whalers - was sailing near Macquarie Island.

"The government strongly objects to whaling vessels passing through Australian territorial seas or our exclusive economic zone," Mr Burke said in a statement late on Thursday.

"Our embassy in Tokyo has conveyed these sentiments directly to the Japanese government."

The Japanese fleet set sail for the Southern Ocean late last year. It aims to catch up to 935 minke whales and up to 50 fin whales.

In recent years, however, it has ended the season well short of these numbers because of disruption caused by conservation group Sea Shepherd, which follows the fleet south each year.

Last year the whalers were granted an injunction by a US court banning Sea Shepherd from coming within 500 yards. Sea Shepherd have questioned the legality of the ruling and have sailed south to track the fleet.

Source: http://www.bbc.co.uk/news/world-asia-21289000#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Friday, February 1, 2013

Freedom returns to the storied city of Timbuktu

Women dance openly in front of a photographer as they walk along a street in Timbuktu, Mali, Thursday Jan. 31, 2013. Many things have changed in Timbuktu since the Islamic militants ceased to enforce their law and relinquished power to French special forces who parachuted in several days ago, liberating this storied city, and now there is a growing sense of freedom. (AP Photo/Harouna Traore)

Women dance openly in front of a photographer as they walk along a street in Timbuktu, Mali, Thursday Jan. 31, 2013. Many things have changed in Timbuktu since the Islamic militants ceased to enforce their law and relinquished power to French special forces who parachuted in several days ago, liberating this storied city, and now there is a growing sense of freedom. (AP Photo/Harouna Traore)

French soldiers are watched by local people, as they drive through the city streets of Timbuktu, Mali, Thursday Jan. 31, 2013. Many things have changed in Timbuktu since the Islamic militants ceased to enforce their law and relinquished power to French special forces who parachuted in several days ago, liberating this storied city, and now there is a growing sense of freedom. (AP Photo/Harouna Traore)

A man walks openly while holding a radio and watched by others, in a street in Timbuktu, Thursday Jan. 31, 2013. Many things have changed in Timbuktu since the Islamic militants ceased to enforce their law and relinquished power to French special forces who parachuted in several days ago and liberated this storied city, and now there is a growing sense of freedom. (AP Photo/Harouna Traore)

French military personnel stand next to a transport aircraft in Timbuktu, Mali, Thursday, Jan. 31, 2013. Several days after French special forces parachuted in and liberated this storied city, there is a growing sense of freedom. Though in the houses immediately facing the Islamic tribunal, many of the 8- and 9-year-old girls are still wearing the head covering. (AP Photo/Harouna Traore)

(AP) ? On the morning French commandos parachuted onto the sand just north of this storied city and ended 10 months of Islamic rule, Hawi Traore folded up her veil. On the next day, she wore heels. On the day after, she put on her sparkly earrings, got her hair braided and tried her mother's perfume.

Finally on Thursday, the 12-year-old girl dared to dance in the streets, celebrating freedom from the draconian rules that were imposed by the al-Qaida-linked militants on this desert capital for much of the past year.

Four days since French special forces liberated Timbuktu, there is a growing sense of freedom ? particularly among women. The speed with which women have claimed back their freedom underscores one of the advantages the French hold against an elusive enemy on unforgiving terrain: The population here has long practiced a moderate Islam rather than the extremism of the militants.

Although Timbuktu has long been a code word for the ends of the earth, until recently its women led a relatively modern existence, where they were not required to be covered and could socialize with men. That changed abruptly last year, when radical Islamists seized control of the northern half of Mali in the chaos after a coup in the distant capital.

When they first arrived, Hawi, a tall, fast-talking, sassy preteen girl, was just learning how to put on makeup. She learned the hard way to wear the toungou, the word for veil in the Songhai language. Her slender arm still bears the scar left by the whip of the Islamic police, her punishment for not properly covering up.

Her once-free life became increasingly restricted, as did that of her sisters and friends.

The Islamists showed no mercy, beating everyone from pregnant women to grandmothers to 9-year-old girls who weren't fully covered. Even talking to a brother on the front stoop of a woman's own home could get her in trouble.

Smoking, drinking and music were banned. So was playing soccer. The worst punishment was reserved for love outside the rules, and an unmarried couple who had two children out of wedlock was stoned to death in one northern Malian town.

Fatouma Traore lives on Street No. 415 in Timbuktu, the road that runs directly in front of the building where the Islamic Tribunal operated in what was once a luxury, boutique hotel. A leaflet left in the dirt in the courtyard set out eight rules for how women should wear the veil.

Rule No. 1 is that the fabric should cover the entire body. Rule No. 2 is that it can't be transparent. Rule No. 3 is that it needs to be colorless. And finally, Rule No. 8 states that a woman should not perfume herself after putting it on.

"We even bought a veil for this baby," said the 21-year-old Traore, picking up her 1-year-old niece and hoisting her on one hip. "Even if you are wearing the veil and it happens to slip off and you are trying to put it back on, they hit you."

The French military launched an intervention to oust the Islamists from power in northern Mali on Jan. 11, and rapidly forced their retreat from the major cities in less than three weeks.

The French arrived here before midnight on Monday in a platoon of 600 soldiers, accompanied by 200 Malian troops. They included paratroopers flown in from a base in Corsica, who landed in the north under the cover of darkness, as well as a convoy of 150 armored vehicles which simultaneously reached the town's western perimeter, according to a French military spokeswoman.

The Islamists were nowhere to be found. They had vanished into the desert, leaving behind a terrorized population and obstacles for the French.

A plane was parked sideways in the middle of the runway at the airport to prevent other aircrafts from landing. Satellite photos showed the runway was also covered with evenly spaced mounds of dirt, said France's Defense Ministry on Thursday. Fearing hidden mines, the French called in specialists with heavy equipment to clear the three-kilometer (1.8-mile)-long landing strip after the damage by the Islamists.

"They destroyed parts of the runway. They removed sections of the asphalt. They destroyed the control tower. We had to control it to make sure that it was not mined," said Capt. Frederic, in charge of communication in Mali for France's 3rd Mechanized Brigade, who could only be identified by his first name in keeping with French military protocol.

Once the airport was secure, the troops rolled into this city of earthen, dun-colored homes in a massive convoy.

They drew crowds so thick that at times, the armored personnel carriers came to a standstill. People waved homemade French flags sewn together from bolts of red, white and blue fabric. Hawi and her mother stood on the side of the road, screaming, "Vive la France!"

The ecstatic women greeting the French were still covered in the all-enveloping veils imposed on them by the former Taliban-inspired occupiers. But hours after watching the French arrival, Hawi went home, folded up her veil and stuffed it away in her closet.

That same day, she pulled out the traditional pagne worn by women in much of sub-Saharan Africa. The Islamists considered it indecent because it was colorful and revealed the shoulders, arms and upper back.

By Tuesday, she dared to wear a pair of heels ? also haram, or "forbidden" by the Islamic regime.

By Wednesday, she had found a newly opened women's hair salon, where she had her hair braided for the first time in months. She opened her jewelry box and put on two bright cube-shaped earrings. Her mother pulled out her eyeliner.

It was on Thursday that they rummaged through their closet and found the envelope where they had hidden their Samsung phone's memory card.

The Islamists had banned music of all kinds, including radios. When they realized young people were still listening to music using earphones, they began policing phones. During the final stages of the occupation, even ringtones became haram. People could not figure out how to change their cellphone settings, so for months many simply placed their phones on silent or on vibrate.

On Thursday, Hawi and her mother took out the memory card with the songs of a musician, a native of a village just 45 kilometers from the city. They went into the street, held up the tiny Samsung phone like a boombox and danced as they pumped it into the air.

Like her daughter, Hawi's mother, Fatouma Arby, also has a scar ? on her right wrist where the Islamic police lashed her after they found her standing outside her house. The Islamists had gradually expanded the public space where women were restricted from the town center, to the alleys blanketed in sand running like veins across Timbuktu, all the way to the threshold of their own homes.

They had even created a prison just for women the likes of Arby, a feisty, 40-something mother and tomboy who exulted Thursday in her release.

"It's been a very long time since I put on makeup," she said, running her finger under her eye to show off the line of black kohl accenting it. "I've put it on to make myself beautiful. So that men see me, and find me beautiful."

A man she knows, a distant cousin, called out her name. She ran over to him and teasingly pulled his arm, as he pulled her back.

It was a tug-of-war between two people who for nearly a year could not so much as touch.

___

Associated Press writer Baba Ahmed contributed to this report from Timbuktu, Mali.

Rukmini Callimachi can be reached at www.twitter.com/rcallimachi.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-01-Mali-Timbuktu/id-cbb795cdbc9b454aaba5faf4244844f5

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Second victim of Phoenix workplace shooting dies

Markow-Kent Photography, Beth Entringer via AP

Mark Hummels was representing Steve Singer in litigation with Arthur Douglas Harmon of Phoenix. Harmon was found dead Thursday of an apparently self-inflicted gunshot wound.

By M. Alex Johnson, staff writer, NBC News

A prominent Arizona lawyer has become the second victim to die in this week's workplace shooting in Phoenix, his law firm said Friday.

Mark Hummels, 43, president of the Phoenix chapter of the Federal Bar Association, died Thursday night, according to the law firm, Osborn Maledon PA.

Hummels had been on life support since he was shot Wednesday following a settlement conference between his client, who was also killed, and the gunman, identified as Arthur Douglas Harmon, 70, of Phoenix.

Hummels was representing Steve Singer, 48, chief executive of Fusion Contact Centers, whom Harmon was suing. Singer died shortly after the shootings Wednesday, and Harmon was found dead of an apparently self-inflicted gunshot wound early Thursday in Mesa, Ariz.

A 32-year-old woman was also shot, but her injuries weren't life-threatening.


Fusion, which operates call centers for businesses, had hired Harmon to do refurbishing work at two of its centers in California. In April, Harmon sued the company for allegedly having failed to pay him in full. The company countersued, demanding that he repay what he had already been paid because the work couldn't be completed.

Documents in the lawsuit include threatening letters from Harmon to Hummels, who wanted to depose Harmon and eventually got a subpoena compelling him to testify under oath, a prospect Harmon said in an email message made him "ill."

"Stop sending your harassing and intimidating e-mails," Harmon said in one email message.

In a letter Dec. 15, Harmon told Hummels: "I will expose you for what you are, depriving me and my family of requested documents to prove my case."

The last communication from Harmon in the case threatened to pursue criminal charges against both Hummels and Singer. Harmon did file a complaint with the Arizona Bar, which dismissed it as being without merit.

Hummels began his career as a reporter for the Santa Fe New Mexican before entering the University of Arizona law school. He graduated first in his class and later was a clerk for 9th Circuit U.S. Appeals Judge Andrew Hurwitz when Hurwitz was an Arizona Supreme Court justice in 2004, NBC station KPNX of Phoenix reported.

Hurwitz called Hummels "the most decent and humble man I have ever met."

In a statement, Hummels' law firm said it was "devastated at this news about our beloved friend" and offered sympathy and support for his wife and two children.

Watch US News crime videos on NBCNews.com

Source: http://usnews.nbcnews.com/_news/2013/02/01/16807875-second-victim-of-phoenix-workplace-shooting-dies?lite

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Backfire ? An Argument That OA Is Better for Non-Profit Societies ...

English: A Coke pin

English: A Coke pin (Photo credit: Wikipedia)

Recently, Stuart Shieber, Director of the Office for Scholarly Communication at Harvard published the edited text of a talk he gave at the annual meeting of the Linguistic Society of America, in which he praised open access (OA) as a better system for learned societies. This is an important topic, especially now because? Parliamentary hearings are going on in the UK exploring how RCUK mandates may affect learned societies.

Judging from the text, Shieber?s talk argued points his facts directly undercut, argued facts he didn?t understand, and asserted realities that don?t exist, yet he failed to realize any of this.

Shieber is a relentless advocate of OA publishing, and has been a force at Harvard driving their policies in this regard. In his recent post, Shieber argues that not-for-profit publishers are more efficient than commercial publishers because they command a lower price in the market for their goods, don?t engage nearly as much in bundling, and have smaller margins. This interpretation of the facts has four obvious problems:

  • Commercial publishers often publish on behalf of not-for-profit societies.
  • Commanding a higher price in the market is a sign of efficiency and effectiveness.
  • Having larger margins is a sign of efficiency.
  • Bundling is a sign of scale, which can only occur if there is efficiency.

In short, Shieber is looking through the wrong end of the binoculars. Of course, his main argument hinges on a related piece of equally spurious logic:

. . . the reason that scholarly societies benefit from playing in the open-access APC market rather than the closed-access subscription fee market is the difference in the goods being sold. When the good is a journal bundle, the companies with the biggest bundles, the large commercial publishers, win. When the good is publisher services for an individual article, the publishers that can deliver those services for an individual article most efficiently, the non-profit publishers, win. Sure, there are economies of scale, but empirical evidence shows that the scholarly societies are already far better able to efficiently deliver services despite any scale disadvantage.

As we?ll see, Shieber?s ?empirical evidence? is inadequate. He hasn?t parsed the market correctly. And the superior profitability and price advantages of publications going through a commercial publisher ? whether those publications are owned by a non-profit society or the commercial publisher ? make a mockery of this line of reasoning. In fact, OA will probably be done more efficiently by large commercial publishers ? viz, the acquisition of BioMed Central by Springer.

Basic business tenets also work against his argument. Every business has a core set of functions ? IT, legal, HR, finance, facilities, insurance, and so forth. If the organization is small, those functions take up a large proportion of revenues and staff. The organization is comparatively inefficient. Larger organizations can use systems, time zones, currency hedges, and many other techniques to increase efficiency, making the money they spend go farther. They also tend to have lower overheads ? less of their revenues devoted to supporting core functions.

The assertion that commercial publishers are less efficient than non-profit publishers is just wrong. Laughably wrong. Their margins are better, their market penetration is better, and their sales forces are better. That?s why so many non-profit societies sign contracts with commercial publishers. They want the benefits these organizations can and do deliver. And there is a reason these organizations can beat the status quo of running publications in-house ? they are more efficient and effective.

Of course, nothing can dissuade the true believer from the assertion that OA is superior. So, we get a litany of facts and reasoning. Let?s examine Shieber?s facts and reason a little more closely to see how much they have to be elided to fit the argument.

To start, Shieber uses the economic concept of a ?complement? incorrectly, asserting that two journals complement each other in the same way hot dogs and hot dog buns complement each other. That is, when hot dog sales fall, hot dog bun sales fall. That kind of relationship does not exist between journals. It exists between audiences and journals ? if there are no more druids, druidic journals disappear, for example. But Journal A?s usage doesn?t drive Journal?s B usage in any appreciable and direct way. His use of the term smacks of sophistry.

Cherry-picked facts come next. Shieber compares subscription prices between commercial and not-for-profit journals. The data he uses are a decade old, from 2002. Unfortunately, the comparison doesn?t represent reality in any year ? commercial publishers publish not-for-profit society journals. A potentially enlightening comparison would be to compare three different cohorts:

  1. Journals owned by for-profit publishers with no not-for-profit involved
  2. Society-owned journals published by commercial publishers
  3. Society-owned journals published independently

Despite using economic concepts incorrectly, having the wrong framework, and relying on outdated facts, Shieber argues on. His main observation is that price differentials are a clear sign of market failure. He?s right ? in a commodity-based market. His example is Coke vs. Pepsi. These are cola commodities. While it pains me to admit, I will settle for a Pepsi when Coke isn?t available. They are, to some degree, interchangeable. But in a market that has differentiated goods, prices diverge. Think about the difference in price between a Scion and a Lexus ? both made by the same company, both automobiles, but brand and features differentiate their prices significantly. Price divergence is not a sign of a malfunctioning market of differentiated, non-commodity goods. Think First Class vs. coach. Think Godiva vs. Nestl?. Think Nordstrom vs. Wal-Mart. Shieber?s economic analysis is simply wrong.

Sheiber?s thinking doesn?t even make internal sense. He notes that APCs vary greatly, ranging in his expert opinion from $0 to $3,000 (in reality, there are higher APCs on the market already). If OA is selling a commodity (peer-review, copy editing, and publication), how could prices diverge like this? And wasn?t he just claiming that price divergence is by definition a sign of a dysfunctional market? Therefore, is the OA market already broken?

He points to more out-of-date data to assert that most OA journals don?t charge APCs. It?s from a 2009 post of his examining 2007 data. The data set is no longer available via the link Shieber provides, but it?s probably irrelevant anyhow. Things have changed significantly. How much have things changed? Well, 2007 is when PLoS ONE launched. In 2008, BioMed Central was acquired by Springer. The NIH Public Access policy went into effect in 2008. And so forth. These data are from a different era.

Sheiber also brags about how Harvard was the first university to resist the ?Big Deal,? but then goes on to explain how disaggregating the Big Deal landed them back at the same place, but with less to show for it. That is, they ended up paying as much as they?d paid before, but for 30 journals rather than the 130 they?d had through bundling. This hurts two of his points. Apparently, bundling is an efficient way to sell and buy journals, proving that commercial publishers are more efficient in the market. Also, it?s apparent that the best journals in the bundle is what Harvard was paying for, but in the bundle they also received some strong second- and third-tier journals, many of which probably came from non-profit societies using Elsevier as their publisher. This is what bundles do ? they help send revenues across more titles, many of which come from small societies. Bundles help smaller societies. Therefore, bundling is a boon to non-profit societies using commercial publishers.

But, of course, Shieber?s goal is to convince us that OA is better for not-for-profit societies. To find a more current source of information, let?s look at an example that emerged from the Parliamentary hearings on the same day that Shieber?s post was published. In this example, we?re dealing with a UK non-profit society (the Tavistock Institute) that gleans $1,633,565 per year in revenues by publishing 60 articles per year in the journal Human Relations. Their publisher is SAGE, a commercial publisher. If the Tavistock Institute were to go to a complete OA model with attendant CC-BY licenses, the Institute would make $90,000 per year at Shieber?s proposed rate of $1,500 per article. In other words, their journal would lose $1,543,565 in revenues by shifting to OA. How does this help the Tavistock Institute?

This kind of trade-off isn?t uncommon, and it?s why societies are so concerned about unthinking mandates and policy shifts. You can see this example and many more in the public evidence available online for the UK?s Parliamentary proceedings.

Shieber throws accusations with abandon. Does the Big Deal violate anti-trust regulations? He points to a 2004 paper ? one single paper ? that suggested it may. What has happened in the last eight years? Based on my online searches, the answer is, ?Nothing.? There was one speculative paper, and then crickets. Shieber uses the empty rhetorical trick of playing organ music to evoke anxiety.

Finally, Shieber notes that 600 scholarly societies publish OA journals. However, when you begin clicking on links in the list he points to, a 404 error or being sent to a society home page is a very likely result. It seems many of these journals have gone by the boards ? journals that seem to be identified with the designation ?Transfer to publisher? or ?Transfer to society.? Others I looked at are publishing an article every week or two, hardly enough to sustain a robust journal?s infrastructure.

But back to the fundamental question: Is OA better for non-profit societies? Judging from what Shieber is inadvertently telling us, I?d be very concerned if I were running a not-for-profit learned society, especially in the UK. Not only are facts being twisted by OA advocates to suit a narrative, but once those facts are placed in a sensible tableau, the picture that emerges is one full of risk and penury.

Source: http://scholarlykitchen.sspnet.org/2013/01/31/backfire-an-argument-that-oa-is-better-for-non-profit-societies-demonstrates-just-the-opposite/

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